With kayexalate gone, there seems to be a gap in our treatment regimen. The fdaapproved product labeling recommends using an exchange rate of 1 meq of potassium per gram of resin as the basis for calculating the dosage for infants and small children. This is provided by administering 15 grams approximately 4 level teaspoons of kayexalate one to four times daily. Glucose and insulin infusion versus kayexalate for the. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is. Usbased mds, dos, nps and pas in fulltime patient practice can register for free on. Fda requires drug interaction studies with potassiumlowering drug kayexalate sodium polystyrene sulfonate. I was just wondering if anyone knows how long kayexalate continues to work in the body, as i have had trouble finding halflife information on this drug. So yesterday afternoon when my tooth pain became agonising i took doses of paracetamol every 4. Doses of 40100 meq per day or more are used for the treatment of potassium depletion. Management of severe hyperkalemia in the postkayexalate era. Dosage should be divided if more than 20 meq per day is given such that no more than 20 meq is given in a single dose. Hypoglycemia secondary to iv insulin administration is a welldocumented complication in the treatment of hyperkalemia. The related drug information index provides comprehensive access to all drug information related to a specific drug types of content include full prescribing information, drug summaries, full prescribing information continuing medication education full pi cme, medication guides, risk evaluation and mitigation strategies rems summaries, rems continuing medication education rems cme, and.
Oral sodium polystyrene sulfonate kayexalate has been shown to reduce lithium concentrations after a single dose or multiple crushrelated acute kidney injury view in chinese of the potassiumbinding resin, sodium polystyrene sulfonate, in combination with 33 percent sorbitol at a 1. They are also used as to remove potassium, calcium, and sodium from solutions in technical applications. For patients with gastroparesis, a 6hour separation should be considered see drug interactions and dosage and administration, adults, including the elderly. Kayexalate prescription and dosage sizes information for physicians and healthcare professionals. Detailed dosage guidelines and administration information for kayexalate sodium polystyrene sulfonate. Sps, kayexalate sodium polystyrene sulfonate dosing. Use the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Kayexalate sodium polystyrene sulfonate basics, side. The food, drug, and cosmetic act fdca was passed in 1938. These therapies included insulin, intravenous sodium bicarbonate, inhaled betaagonists.
This helps prevent your body from absorbing too much potassium. The fda first approved kayexalate for the treatment of hyperkalemia on june 5, 1958, 4 years before passage of the kefauverharris drug amendments, which require drug manufacturers to prove the effectiveness and safety of their products before marketing them. Kayexalate, brand of sodium polystyrene sulfonate is a benzene. This drug has been a standard part of treatment of hyperkalemia for decades. Capitals indicate lifethreatening, underlines indicate most frequent.
If you are taking this medication by mouth, take it usually 1 to 4 times a day as directed by your doctor. Colonic necrosis due to sodium polystyrene sulfate kayexalate. Kayexalate, brand of sodium polystyrene sulfonate is a benzene, diethenylpolymer, with ethenylbenzene, sulfonated, sodium salt and has the following structural formula. Kayexalate fda prescribing information, side effects and. A 15 g dose is equivalent to approximately 4 level teaspoons. What happens if i miss a dose kalexate, kayexalate, kionex. To prepare the liquid suspension, carefully measure the prescribed dose of the powder and mix it with the prescribed amount of water or flavored syrup as directed. Kayexalate was administered without following proper indications defined as moderate to severe hyperkalemia, with absolute contraindications, or with drug. Taking a second look at kayexalate pubmed central pmc.
This drug can continue to control the potassium for hours and, despite the modest sodium load it entails, can be effective as a temporizing measure until dialysis if. Does kayexalate have a role in the ed management of. Rectal the average adult dose is 30 g to 50 g every six hours. All the information, content and live chat provided on the site is intended to be for informational purposes only, and not a substitute for professional or medical advice. I often encounter residents who know that kayexalate isnt helpful, but arent sure exactly how to treat. Started in 1995, this collection now contains 6767 interlinked topic pages divided into a tree of 31 specialty books and 732 chapters. The average total daily adult dose of kayexalate is 15 g to 60 g, administered as a 15g dose four level teaspoons, one to four times daily. Treatment and prevention of hyperkalemia in adults uptodate. The dose for the prevention of hypokalemia is typically in the range of 20 meq per day. Kayexalate binds itself to potassium in your digestive tract. One hundred ninetyeight events met the inclusion criteria and were included in the final analysis. Hyperkalemia is a common clinical problem that is most often a result of impaired urinary potassium excretion due to acute or chronic kidney disease ckd andor disorders or drugs that inhibit the reninangiotensinaldosterone system raas. Gastrointestinal adverse events with sodium polystyrene sulfonate kayexalate use. Seek emergency medical attention or call the poison help line at 18002221222.
Medscape hyperkalemia dosing for sps, kayexalate sodium polystyrene. Ketalar ketamine dosing, indications, interactions. In severe hyperkalemia, consider more immediate treatment modalities eg, dialysis, iv calcium, bicarbonate, glucose, and insulin products can contain as much as 20 g of sorbitol per 15 g of sodium polystyrene use caution with dosage forms containing propylene glycol. In severe hyperkalemia, consider more immediate treatment modalities eg, dialysis, iv calcium, bicarbonate, glucose, and insulin products can contain as much as. The dose may be increased or decreased, as necessary, to reach the desired serum potassium concentration, up to a maximum dosage of 25. This is best provided by administering 15 g approximately 4.
For patients not taking glucuronidation inducers, may need to increase or decrease lamotrigine dose if atazanavirritonavir is added or discontinued, respectively. Kayexalate sodium polystyrene sulfonate side effects. How long does oral kayexalate continue to work in the body. Kayexalate is a brand name of the prescription drug sodium polystyrene sulfonate, used to treat high potassium levels in the blood hyperkalemia. Administer kayexalate at least 3 hours before or 3 hours after administration of other oral medications. Therapy for hyperkalemia due to potassium retention is ultimately aimed at inducing potassium loss 1,2. Sodium polystyrene sulfonate kayexalate, sanofiaventis, bridgemater, nj is a. Common side effects include loss of appetite, gastrointestinal upset. In 1 patient, a dose of 144 meq given over 5 minutes led to a fall of. This drug should be given as a suspension in water or syrup not fruit juice. The use of singledose sps monotherapy resulted in a significant decrease in serum.
Sps, kayexalate sodium polystyrene sulfonate dosing, indications. The average daily adult dose of the resin is 15 to 60 grams. A dose of 10 units iv insulin regular has been estimated to lower serum potassium levels by 0. Kayexalate sodium polystyrene sulfonate sps cation exchange resin exchanges na for excreted potassium in the gut most exchange takes place in the colon each gram can bind 0. Kayexalate sodium polystyerene sulfonate is a cationexchange resin that was approved in 1958 as a treatment for hyperkalemia by helping to exchange sodium for potassium in the colon and thus excreting potassium from the body. Kayexalate is used to treat high levels of potassium in the blood, also called hyperkalemia kayexalate works differently from other medicines because it passes into your intestines without being absorbed into your blood stream. In kayexalate group n 20, the dose of kayexalate was 1 gmkg body weight given rectally every four hours. Event reports were included if insulin was used for. There is increasing recognition that sodium polystyrene sulfonate kayexalate is ineffective for the immediate management of severe hyperkalemia kamel 2012. Fda requires drug interaction studies with potassiumlowering drug kayexalate sodium. At each clinical setting, physicians and other providers should evaluate drug, equipment, and training needs. Learn about drug interactions between calcium chloride iv and sodium polystyrene sulfonate oral and use the rxlist drug interaction checker to check drug combinations.
The average daily adult dose of the resin is 15 g to 60 g. Kayexalate from all other oral drugs this information is an update to the fda drug safety communication. This drug should be administered via warm emulsion in 100 ml of aqueous vehicle. Drugs for pediatric emergencies committee on drugs abstract. Does kayexalate have a role in the ed management of hyperkalemia. Pharmacology, adverse reactions, warnings and side effects. Kayexalate powder dosing doctor answers on healthcaremagic. Polystyrene sulfonates are a group of medications used to treat high blood potassium. What happens if i overdose kalexate, kayexalate, kionex. Is kayexalate useful in the treatment of hyperkalemia in. Maintenance doses may be lower than initial doses and should be adjusted according to individual patient. Does kayexalate oral powder interact with other medications. Avoid additional harm when using insulin and dextrose authors staley lawes, pharmd, bcps, fismp.
Singledose sodium polystyrene sulfonate for hyperkalemia in. A, on computed tomographic scan of the abdomen, with iv and oral contrast, a focal. Kayexalate medicare coverage and copay details goodrx. Medicare coverage and pricing details for kayexalate.
Risk factors for hypoglycemia during treatment with insulin. Potassiumbinding agents for the clinical management of. Learn more about medicare prescription drug plans and savings with goodrx. Drugs az pill identifier supplements symptom checker diseases dictionary media. All treatment discontinued after the serum potassium level returned to normal for 6 hours. Sodium polystyrene sulfonate dosage guide with precautions.